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Ansamitocin P-3
CAS No. 66547-09-9
Ansamitocin P-3( Maytansinol butyrate )
Catalog No. M15536 CAS No. 66547-09-9
A microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria; binds tubulin (Kd=1.3 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 113 | In Stock |
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| 25MG | 222 | In Stock |
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| 50MG | 361 | In Stock |
|
| 100MG | 537 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAnsamitocin P-3
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NoteResearch use only, not for human use.
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Brief DescriptionA microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria; binds tubulin (Kd=1.3 uM).
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DescriptionA microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria; binds tubulin (Kd=1.3 uM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation; inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice.
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In Vitro——
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In Vivo——
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SynonymsMaytansinol butyrate
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PathwayAntibody Drug Conjugates (ADC)
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TargetADC Cytotoxin
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Recptormicrotubule
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number66547-09-9
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Formula Weight635.1448
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Molecular FormulaC32H43ClN2O9
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)C(C)C)C)\C)OC)(NC(=O)O2)O
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Chemical NameMaytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ootsu K, et al. Cancer Res. 1980 May;40(5):1707-17.
2. Venghateri JB, et al. PLoS One. 2013 Oct 4;8(10):e75182.
3. Martin K, et al. Cancer Immunol Immunother. 2014 Sep;63(9):925-38.
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